3-HO-PCP HCL

Buy 3-HO-PCP HCL online

What is 3-HO-PCP?

Buy 3-HO-PCP HCL , 3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance from the arylcyclohexylamine class that produces potent dissociative, hallucinogenic and euphoric effects when administered. In addition to its primary activity as an NMDA receptor antagonist, it has been found to have considerable affinity for the μ-opioid receptor .

3-HO-PCP was first synthesized in 1978 to study the structure-activity relationship of phencyclidine (PCP) derivatives. In the 1980s, it was further investigated along with PCP, where it was discovered to possess μ-opioid agonist activity in animal models.

Like other substances in its class, notably methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is known to primarily induce a state called “dissociative anesthesia,” although the extent to which this occurs has not been previously reported. The effect is highly dose-dependent and variable. It is not known whether the opioid properties studied in animal models are applicable to humans, but some early reports suggest that this is not the case .

Today, 3-HO-PCP is sold almost exclusively as a research chemical in the gray area of ​​online retailers. Very little is known about its pharmacology, metabolism, and toxicity in humans. Due to its sensitive dose-response relationship, potentially addictive properties, and unknown toxicity profile, it is strongly recommended that appropriate harm reduction measures be used when using this substance.

Chemical Properties

3-HO-PCP or 3-hydroxyphencyclidine is a synthetic dissociative from the class of arylcyclohexylamines. The structure of 3-HO-PCP consists of cyclohexane, a six-membered saturated ring, attached to R1 by two additional rings. One of these rings is a piperidine ring, a nitrogen-containing six-membered ring attached to its nitrogen group. The other ring is an aromatic phenyl ring substituted with a hydroxy group at R3.

3-HO-PCP is a structural analogue of PCP and a homologue 3-MeO-PCP.

Pharmacological effects

Like other arylcyclohexylamine dissociatives, 3-HO-PCP acts primarily as an NMDA receptor antagonist. The NMDA receptor (N-methyl-D-aspartate), a specific subtype of the glutamate receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord. In order for the signals to pass, the receptor must be open. Dissociatives inhibit the normally functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity, some research suggests, leads to network disintegration through hyperconnectivity throughout the brain. This leads to an increase in noise (random, nonsense and erroneous data) in the brain network and thus leads to the loss of normal cognitive and affective processing, psychomotor function and anesthesia. This is often observed in individuals exhibiting psychosis or induced by high doses of intravenous THC or ketamine in healthy participants.

In contrast to many other dissociatives, 3-HO-PCP has also been found to have significant affinity as a μ-opioid receptor agonist in animal models. However, the extent to which this applies to humans is not yet known.

Some of the most commonly reported effects include:

stimulation

Spontaneous body sensations

fear suppression

Physical and cognitive euphoria

touch improvement

Possible side effects

sedation

conceptual thinking

Already seen

orgasm suppression

ego death

legality

3-HO-PCP is classified as illegal in:

Great Britain

Switzerland

Sweden

turkey

This list is not exhaustive. Please inform yourself about the legal status in your country before ordering!

How to buy 3-HO-PCP

You can buy 3-HO-PCP and other dissociatives like 3-HO-PCE, 3-MeO-PCP and DCK here at Chems Planet. All of our chemicals are third party lab tested.

All our chemicals are intended for research and analytical purposes only and are not intended for human consumption.